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KMID : 1123920100240030385
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.385 ~ p.389
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Apoptosis Induction of MCF-7 Human Breast Carcinoma Cells by Butein
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Song Ba-Da
Kim Sun-Rye
Kim Sung-Hoon
Shin Yong-Chul
Ko Seong-Gyu
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Abstract
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Butein(3,4,2’,4-tetrahydroxychalcone) has been reported anticancer effects in several cancer type, which is prostate, bladder cancer but breast cancer is not. This study was to investigate the antiproliferative effects by butein(3,4,2’,4-tetrahydroxychalcone) in MCF-7 human breast carcinoma cells. We invastigated the effects of dose-dependently cell growth inhibition by butein, which could be proved by WST-1 assay. Also, flow cytometry analysis was butein increase percentage of subG1 phase. As well as, butein induces apoptosis through the expression of caspase-8,-3 and poly(ADP-ribose) polymerase(PARP) activation but not in DMSO treated cells. Taken together, this results suggest that butein induced MCF-7 apoptosis through extrinsic pathway and thus may have potential tumor suppressor in breast cancer.
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KEYWORD
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Butein(3, 4, 2’, 4-tetrahydroxychalcone), apoptosis, extrinsic pathway, PARP(poly(ADP-ribose) polymerase)
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